丽珠肠乐和氟西汀合用治疗腹泻型肠易激综合征的疗效观察

时间:2020-10-06 10:31:06 医学毕业论文 我要投稿

丽珠肠乐和氟西汀合用治疗腹泻型肠易激综合征的疗效观察

丽珠肠乐和氟西汀合用治疗腹泻型肠易激综合征的'疗效观察

【关键词】 ,丽珠肠乐

摘 要:目的:研究丽珠肠乐和氟西汀合用治疗腹泻型肠易激综合征(IBS)的临床疗效。方法:对54例腹泻型肠易激综合征病人随机分为治疗组30例和对照组24例,治疗组口服丽珠肠乐胶囊0.7g(2粒),每日2次,氟西汀胶囊10mg,每日2次,用8周。对照组口服丽珠肠乐胶囊0.7g,每日2次,用8周。结果:治疗组完全缓解14例(46.7%),部分缓解12例(40%),不缓解4例(13.3%),总有效率为86.7%,对照组完全缓解4例(16.7%),部分缓解11例(45.8%),不缓解9例(37.5%),总有效率为62.5%,两组有明显差异(P<0.05)。结论:丽珠肠乐和氟西汀合用治疗腹泻型肠易激综合征疗效好,副作用少,尤其适用于伴有明显心理障碍的病人。

  关键词: 腹泻型肠易激综合征; 丽珠肠乐; 氟西汀

  Observe the Curative Effect of Livzon Bifidobacterium Preparation and Fluoxetine on Diarrehea-predominant Pattern Irritable Bowel Syndrome

  Abstract:Objective:To investigate the curative effect of livzon bifidobacterium preparation and fluoxetine on irritable bowel syndrome.Methods:54 patients with diarrehea-predominant pattern irritable bowel syndrome were enrolled in this study.The patients were divided into two groups:30 patients in curative group and 24 patients in control group.The patient of curative group takes livzon bifidobacterium preparation capsule 0.7g,b.i.d,and fluoxetine capsule 10mg,b.i.d.for 8 weeks .The patient of control group takes livzon bifidobacterium preparation capsule 0.7g,b.i.d.for 8 weeks.Results: In the curative group 14 patients were complete remission(46.7%),12 patients were part remission(40%),4 patients were not remission(13.3%).The total effective rate are 86.7%.In the control group 4 patients were remission(16.7%),11 patients were part remission (45.8%),9 patients were not remission(37.5%).The total effective rate was 62.5%.The two groups have significant differences(p<0.05).Conclusion: The effect of Livzon bifidobacterium preparation and fluoxetine on diarrehea-predominant pattern irritable bowel syndrome is good.The two medicine have little side effect and especially for patients psychological block.

  Key words: Diarrehea-predominant pattern irritable bowel syndrome; Livzon bifidobacterium preparation; Fluoxetine

  我院1999年至2004年间门诊及内科病房共收治腹泻型IBS病人54例,其中30例病人予以丽珠肠乐和氟西汀合用治疗取得了较好的疗效,现分析如下:

  1 材料与方法

  1.1 一般资料:本组54例均符合罗马Ⅱ标准,并经生化检查、内镜、B超、X线或CT等影像学检查,排除器质性疾病。所有病人都表现为腹痛、大便次数增多、稀便或水样便,部分病人有焦虑,抑郁和睡眠障碍,病程3个月至10余年。将54例病人随机分为两组,治疗组30例,其中男性14例,女性16例,年龄22~65岁,平均43.5岁。对照组24例,其中男性10例,女性14例,年龄20~68岁,平均44岁。

  1.2 方法:治疗组:口服丽珠肠乐胶囊0.7g(2粒),每日2次,氟西汀胶囊10mg,每日2次,共用8周。对照组:单纯口服丽珠肠乐胶囊0.7g,每日2次,共用8周,治疗完成后继续随防12周。

  1.3 疗效判断标准:①完全缓解:腹痛、腹胀和其他非结肠源性消化道症状(包括烧心、吞咽困难、癔球感或非心源性胸痛、恶心、呕吐等)消失,粪便性状和排便次数基本转为正常。②部分缓解:腹痛、腹胀和其他非结肠源性消化道症状较治疗前改善,排便次数较治疗前减少,粪便性状改变为糊状。③不缓解:腹痛、腹胀和其他非结肠源性消化道症状末改善,排便次数和粪便性状与治疗前无差别。