血小板去除术联合药物治疗原发性血小板增多症22例临床分析
【关键词】 血小板增多,出血性；血小板去除术；羟基脲；干扰素-α［摘要］ 目的 观察血小板去除术联合羟基脲、干扰素-α治疗原发性血小板增多症（PT）的'疗效。方法 对22例PT患者采用血小板去除术1~4次后，立即给予羟基脲和干扰素-α治疗。结果 血小板去除术后，患者外周血中血小板计数明显下降，临床症状好转，再经羟基脲、干扰素-α联合治疗，所有患者病情均得到明显改善。结论 血小板去除术联合羟基脲、干扰素-α治疗PT有显著疗效。
［关键词］ 血小板增多，出血性；血小板去除术；羟基脲；干扰素-α
Treatment of primary thrombocythemia with platelet separation plus medication:Experence of 22 cases
［Abstract］ Objective To observe the clinical effects of platelet separation plus hydroxyurea, INF-α on primary thrombocythemia（PT）. Methods All patients were treated with platelet separation and hydroxyurea, INF-α in turn.Results After platelet separation, the platelet count of patients decreased significantly and the symptoms referable to thrombocythemia were improved. Then, all cases were treated with hydroxyurea, INF-α and got obviously amelioration finally. Conclusion The method of platelet separation plus hydroxyurea and INF-α have significant effects on PT.
［Key words］ thrombocythemia,hemorrhagic;primary;platelet separation;hydroxyurea;interferon-Alpha
原发性血小板增多症（primary thrombocythemia,PT）是一种慢性骨髓增生性疾病，其特点为外周血血小板持续显著增多且功能异常，骨髓巨核细胞增生显著，临床表现常有出血倾向和（或）血栓形成，约半数患者有脾肿大。尽快降低血小板、使血液黏滞度下降，预防血栓及出血的发生是治疗PT的关键。我院于2002年1月~2004年12月采取血小板去除术联合羟基脲、干扰素-α治疗PT患者22例，现将其临床特征及诊疗情况报告如下。
1 资料与方法
1.1 一般资料 22例患者均为住院及门诊随访患者，男12例，女10例；年龄25~73岁，平均48岁。均符合国内的诊断标准［1］，即血小板
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